Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial
Identifieur interne : 008423 ( Main/Exploration ); précédent : 008422; suivant : 008424Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial
Auteurs : B. E. De Galan [Australie, Pays-Bas] ; S. Zoungas [Australie] ; J. Chalmers [Australie] ; C. Anderson [Australie] ; C. Dufouil [France] ; A. Pillai [Australie] ; M. Cooper [Australie] ; D. E. Grobbee [Pays-Bas] ; M. Hackett [Australie] ; P. Hamet [Canada] ; S. R. Heller [Royaume-Uni] ; L. Lisheng [République populaire de Chine] ; S. Macmahon [Australie] ; G. Mancia [Italie] ; B. Neal [Australie] ; C. Y. Pan [République populaire de Chine] ; A. Patel [Australie] ; N. Poulter [Royaume-Uni] ; F. Travert [France] ; M. Woodward [Australie, États-Unis]Source :
- Diabetologia : (Berlin) [ 0012-186X ] ; 2009.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
Abstract
Aims/hypothesis The relationship between cognitive function, cardiovascular disease and premature death is not well established in patients with type 2 diabetes. We assessed the effects of cognitive function in 11,140 patients with type 2 diabetes who participated in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial. Furthermore, we tested whether level of cognitive function altered the beneficial effects of the BP-lowering and glycaemic-control regimens in the trial. Methods Cognitive function was assessed using the Mini Mental State Examination at baseline, and defined by scores 28-30 ('normal', n=8,689), 24-27 ('mild dysfunction', n=2,231) and <24 ('severe dysfunction', n=212). Risks of major cardiovascular events, death and hypoglycaemia and interactions with treatment were assessed using Cox proportional hazards analysis. Results Relative to normal function, both mild and severe cognitive dysfunction significantly increased the multiple-adjusted risks of major cardiovascular events (HR 1.27, 95% CI 1.11-1.46 and 1.42, 95% CI 1.01-1.99; both p< 0.05), cardiovascular death (1.41, 95% CI 1.16-1.71 and 1.56, 95% CI 0.99-2.46; both p<0.05) and all-cause death (1.33, 95% CI 1.16-1.54 and 1.50, 95% CI 1.06-2.12; both p<0.03). Severe, but not mild, cognitive dysfunction increased the risk of severe hypoglycaemia (HR 2.10, 95% CI 1.14-3.87; p=0.018). There was no evidence of heterogeneity of treatment effects on cardiovascular outcomes in subgroups defined by cognitive function at baseline. Conclusions/interpretation Cognitive dysfunction is an independent predictor of clinical outcomes in patients with type 2 diabetes, but does not modify the effects of BP lowering or glucose control on the risks of major cardiovascular events.
Affiliations:
- Australie, Canada, France, Italie, Pays-Bas, Royaume-Uni, République populaire de Chine, États-Unis
- Angleterre, Grand Londres, Gueldre, Lombardie, Nouvelle-Galles du Sud, Utrecht (province), Île-de-France
- Londres, Milan, Nimègue, Paris, Pékin, Sydney, Utrecht
- Université de Sydney
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 002A97
- to stream PascalFrancis, to step Curation: 003527
- to stream PascalFrancis, to step Checkpoint: 002C39
- to stream Main, to step Merge: 008C08
- to stream Main, to step Curation: 008423
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial</title><author><name sortKey="De Galan, B E" sort="De Galan, B E" uniqKey="De Galan B" first="B. E." last="De Galan">B. E. De Galan</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>1 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Zoungas, S" sort="Zoungas, S" uniqKey="Zoungas S" first="S." last="Zoungas">S. Zoungas</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Monash University</s1><s2>Melbourne, VIC</s2><s3>AUS</s3><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Monash University</wicri:noRegion></affiliation></author><author><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Anderson, C" sort="Anderson, C" uniqKey="Anderson C" first="C." last="Anderson">C. Anderson</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Dufouil, C" sort="Dufouil, C" uniqKey="Dufouil C" first="C." last="Dufouil">C. Dufouil</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>INSERM U708</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>UPMC University of Paris</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pillai, A" sort="Pillai, A" uniqKey="Pillai A" first="A." last="Pillai">A. Pillai</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Cooper, M" sort="Cooper, M" uniqKey="Cooper M" first="M." last="Cooper">M. Cooper</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Baker IDI Heart Research Institute</s1><s2>Melbourne, VIC</s2><s3>AUS</s3><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Baker IDI Heart Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Grobbee, D E" sort="Grobbee, D E" uniqKey="Grobbee D" first="D. E." last="Grobbee">D. E. Grobbee</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht</s1><s2>Utrecht</s2><s3>NLD</s3><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Hackett, M" sort="Hackett, M" uniqKey="Hackett M" first="M." last="Hackett">M. Hackett</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Hamet, P" sort="Hamet, P" uniqKey="Hamet P" first="P." last="Hamet">P. Hamet</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Centre Hospitalier de l'Université de Montreal and Université de Montreal</s1><s2>Montreal, QC</s2><s3>CAN</s3><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Centre Hospitalier de l'Université de Montreal and Université de Montreal</wicri:noRegion></affiliation></author><author><name sortKey="Heller, S R" sort="Heller, S R" uniqKey="Heller S" first="S. R." last="Heller">S. R. Heller</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>University of Sheffield and Sheffield Teaching Hospitals National Health Service Foundation Trust</s1><s2>Sheffield</s2><s3>GBR</s3><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>University of Sheffield and Sheffield Teaching Hospitals National Health Service Foundation Trust</wicri:noRegion></affiliation></author><author><name sortKey="Lisheng, L" sort="Lisheng, L" uniqKey="Lisheng L" first="L." last="Lisheng">L. Lisheng</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Chinese Hypertension League Institute</s1><s2>Beijing</s2><s3>CHN</s3><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Macmahon, S" sort="Macmahon, S" uniqKey="Macmahon S" first="S." last="Macmahon">S. Macmahon</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Mancia, G" sort="Mancia, G" uniqKey="Mancia G" first="G." last="Mancia">G. Mancia</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>University of Milan-Bicocca and San Gerardo Hospital</s1><s2>Milan</s2><s3>ITA</s3><sZ>14 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Neal, B" sort="Neal, B" uniqKey="Neal B" first="B." last="Neal">B. Neal</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Pan, C Y" sort="Pan, C Y" uniqKey="Pan C" first="C. Y." last="Pan">C. Y. Pan</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Chinese People's Liberation Army General Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Patel, A" sort="Patel, A" uniqKey="Patel A" first="A." last="Patel">A. Patel</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Poulter, N" sort="Poulter, N" uniqKey="Poulter N" first="N." last="Poulter">N. Poulter</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Imperial College and St Mary's Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>18 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Travert, F" sort="Travert, F" uniqKey="Travert F" first="F." last="Travert">F. Travert</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>UPMC University of Paris</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Woodward, M" sort="Woodward, M" uniqKey="Woodward M" first="M." last="Woodward">M. Woodward</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Mount Sinai School of Medicine</s1><s2>New York, NY</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Mount Sinai School of Medicine</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0447399</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0447399 INIST</idno><idno type="RBID">Pascal:09-0447399</idno><idno type="wicri:Area/PascalFrancis/Corpus">002A97</idno><idno type="wicri:Area/PascalFrancis/Curation">003527</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002C39</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002C39</idno><idno type="wicri:doubleKey">0012-186X:2009:De Galan B:cognitive:function:and</idno><idno type="wicri:Area/Main/Merge">008C08</idno><idno type="wicri:Area/Main/Curation">008423</idno><idno type="wicri:Area/Main/Exploration">008423</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial</title><author><name sortKey="De Galan, B E" sort="De Galan, B E" uniqKey="De Galan B" first="B. E." last="De Galan">B. E. De Galan</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>1 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Zoungas, S" sort="Zoungas, S" uniqKey="Zoungas S" first="S." last="Zoungas">S. Zoungas</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Monash University</s1><s2>Melbourne, VIC</s2><s3>AUS</s3><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Monash University</wicri:noRegion></affiliation></author><author><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Anderson, C" sort="Anderson, C" uniqKey="Anderson C" first="C." last="Anderson">C. Anderson</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Dufouil, C" sort="Dufouil, C" uniqKey="Dufouil C" first="C." last="Dufouil">C. Dufouil</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>INSERM U708</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>UPMC University of Paris</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pillai, A" sort="Pillai, A" uniqKey="Pillai A" first="A." last="Pillai">A. Pillai</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Cooper, M" sort="Cooper, M" uniqKey="Cooper M" first="M." last="Cooper">M. Cooper</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Baker IDI Heart Research Institute</s1><s2>Melbourne, VIC</s2><s3>AUS</s3><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Baker IDI Heart Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Grobbee, D E" sort="Grobbee, D E" uniqKey="Grobbee D" first="D. E." last="Grobbee">D. E. Grobbee</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht</s1><s2>Utrecht</s2><s3>NLD</s3><sZ>8 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Hackett, M" sort="Hackett, M" uniqKey="Hackett M" first="M." last="Hackett">M. Hackett</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Hamet, P" sort="Hamet, P" uniqKey="Hamet P" first="P." last="Hamet">P. Hamet</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Centre Hospitalier de l'Université de Montreal and Université de Montreal</s1><s2>Montreal, QC</s2><s3>CAN</s3><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Centre Hospitalier de l'Université de Montreal and Université de Montreal</wicri:noRegion></affiliation></author><author><name sortKey="Heller, S R" sort="Heller, S R" uniqKey="Heller S" first="S. R." last="Heller">S. R. Heller</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>University of Sheffield and Sheffield Teaching Hospitals National Health Service Foundation Trust</s1><s2>Sheffield</s2><s3>GBR</s3><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>University of Sheffield and Sheffield Teaching Hospitals National Health Service Foundation Trust</wicri:noRegion></affiliation></author><author><name sortKey="Lisheng, L" sort="Lisheng, L" uniqKey="Lisheng L" first="L." last="Lisheng">L. Lisheng</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Chinese Hypertension League Institute</s1><s2>Beijing</s2><s3>CHN</s3><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Macmahon, S" sort="Macmahon, S" uniqKey="Macmahon S" first="S." last="Macmahon">S. Macmahon</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Mancia, G" sort="Mancia, G" uniqKey="Mancia G" first="G." last="Mancia">G. Mancia</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>University of Milan-Bicocca and San Gerardo Hospital</s1><s2>Milan</s2><s3>ITA</s3><sZ>14 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Neal, B" sort="Neal, B" uniqKey="Neal B" first="B." last="Neal">B. Neal</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Pan, C Y" sort="Pan, C Y" uniqKey="Pan C" first="C. Y." last="Pan">C. Y. Pan</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Chinese People's Liberation Army General Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>16 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Patel, A" sort="Patel, A" uniqKey="Patel A" first="A." last="Patel">A. Patel</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Poulter, N" sort="Poulter, N" uniqKey="Poulter N" first="N." last="Poulter">N. Poulter</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Imperial College and St Mary's Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>18 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Travert, F" sort="Travert, F" uniqKey="Travert F" first="F." last="Travert">F. Travert</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>UPMC University of Paris</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Woodward, M" sort="Woodward, M" uniqKey="Woodward M" first="M." last="Woodward">M. Woodward</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Camperdown</s1><s2>Sydney, NSW 2050</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, NSW 2050</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Mount Sinai School of Medicine</s1><s2>New York, NY</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Mount Sinai School of Medicine</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Diabetologia : (Berlin)</title><title level="j" type="abbreviated">Diabetologia : (Berl.)</title><idno type="ISSN">0012-186X</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Diabetologia : (Berlin)</title><title level="j" type="abbreviated">Diabetologia : (Berl.)</title><idno type="ISSN">0012-186X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood pressure</term><term>Cardiovascular disease</term><term>Evaluation</term><term>Glucose</term><term>Human</term><term>Hypoglycemia</term><term>Mortality</term><term>Release</term><term>Type 2 diabetes</term><term>Vascular disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Hypoglycémie</term><term>Pathologie des vaisseaux sanguins</term><term>Libération</term><term>Evaluation</term><term>Pression sanguine</term><term>Pathologie de l'appareil circulatoire</term><term>Diabète de type 2</term><term>Glucose</term><term>Mortalité</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Glucose</term><term>Mortalité</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aims/hypothesis The relationship between cognitive function, cardiovascular disease and premature death is not well established in patients with type 2 diabetes. We assessed the effects of cognitive function in 11,140 patients with type 2 diabetes who participated in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial. Furthermore, we tested whether level of cognitive function altered the beneficial effects of the BP-lowering and glycaemic-control regimens in the trial. Methods Cognitive function was assessed using the Mini Mental State Examination at baseline, and defined by scores 28-30 ('normal', n=8,689), 24-27 ('mild dysfunction', n=2,231) and <24 ('severe dysfunction', n=212). Risks of major cardiovascular events, death and hypoglycaemia and interactions with treatment were assessed using Cox proportional hazards analysis. Results Relative to normal function, both mild and severe cognitive dysfunction significantly increased the multiple-adjusted risks of major cardiovascular events (HR 1.27, 95% CI 1.11-1.46 and 1.42, 95% CI 1.01-1.99; both p< 0.05), cardiovascular death (1.41, 95% CI 1.16-1.71 and 1.56, 95% CI 0.99-2.46; both p<0.05) and all-cause death (1.33, 95% CI 1.16-1.54 and 1.50, 95% CI 1.06-2.12; both p<0.03). Severe, but not mild, cognitive dysfunction increased the risk of severe hypoglycaemia (HR 2.10, 95% CI 1.14-3.87; p=0.018). There was no evidence of heterogeneity of treatment effects on cardiovascular outcomes in subgroups defined by cognitive function at baseline. Conclusions/interpretation Cognitive dysfunction is an independent predictor of clinical outcomes in patients with type 2 diabetes, but does not modify the effects of BP lowering or glucose control on the risks of major cardiovascular events.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Gueldre</li><li>Lombardie</li><li>Nouvelle-Galles du Sud</li><li>Utrecht (province)</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Milan</li><li>Nimègue</li><li>Paris</li><li>Pékin</li><li>Sydney</li><li>Utrecht</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="De Galan, B E" sort="De Galan, B E" uniqKey="De Galan B" first="B. E." last="De Galan">B. E. De Galan</name></region><name sortKey="Anderson, C" sort="Anderson, C" uniqKey="Anderson C" first="C." last="Anderson">C. Anderson</name><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name><name sortKey="Cooper, M" sort="Cooper, M" uniqKey="Cooper M" first="M." last="Cooper">M. Cooper</name><name sortKey="Hackett, M" sort="Hackett, M" uniqKey="Hackett M" first="M." last="Hackett">M. Hackett</name><name sortKey="Macmahon, S" sort="Macmahon, S" uniqKey="Macmahon S" first="S." last="Macmahon">S. Macmahon</name><name sortKey="Neal, B" sort="Neal, B" uniqKey="Neal B" first="B." last="Neal">B. Neal</name><name sortKey="Patel, A" sort="Patel, A" uniqKey="Patel A" first="A." last="Patel">A. Patel</name><name sortKey="Pillai, A" sort="Pillai, A" uniqKey="Pillai A" first="A." last="Pillai">A. Pillai</name><name sortKey="Woodward, M" sort="Woodward, M" uniqKey="Woodward M" first="M." last="Woodward">M. Woodward</name><name sortKey="Zoungas, S" sort="Zoungas, S" uniqKey="Zoungas S" first="S." last="Zoungas">S. Zoungas</name><name sortKey="Zoungas, S" sort="Zoungas, S" uniqKey="Zoungas S" first="S." last="Zoungas">S. Zoungas</name></country><country name="Pays-Bas"><region name="Gueldre"><name sortKey="De Galan, B E" sort="De Galan, B E" uniqKey="De Galan B" first="B. E." last="De Galan">B. E. De Galan</name></region><name sortKey="Grobbee, D E" sort="Grobbee, D E" uniqKey="Grobbee D" first="D. E." last="Grobbee">D. E. Grobbee</name></country><country name="France"><region name="Île-de-France"><name sortKey="Dufouil, C" sort="Dufouil, C" uniqKey="Dufouil C" first="C." last="Dufouil">C. Dufouil</name></region><name sortKey="Dufouil, C" sort="Dufouil, C" uniqKey="Dufouil C" first="C." last="Dufouil">C. Dufouil</name><name sortKey="Travert, F" sort="Travert, F" uniqKey="Travert F" first="F." last="Travert">F. Travert</name></country><country name="Canada"><noRegion><name sortKey="Hamet, P" sort="Hamet, P" uniqKey="Hamet P" first="P." last="Hamet">P. Hamet</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Heller, S R" sort="Heller, S R" uniqKey="Heller S" first="S. R." last="Heller">S. R. Heller</name></noRegion><name sortKey="Poulter, N" sort="Poulter, N" uniqKey="Poulter N" first="N." last="Poulter">N. Poulter</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Lisheng, L" sort="Lisheng, L" uniqKey="Lisheng L" first="L." last="Lisheng">L. Lisheng</name></noRegion><name sortKey="Pan, C Y" sort="Pan, C Y" uniqKey="Pan C" first="C. Y." last="Pan">C. Y. Pan</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Mancia, G" sort="Mancia, G" uniqKey="Mancia G" first="G." last="Mancia">G. Mancia</name></region></country><country name="États-Unis"><noRegion><name sortKey="Woodward, M" sort="Woodward, M" uniqKey="Woodward M" first="M." last="Woodward">M. Woodward</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008423 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 008423 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:09-0447399
|texte= Cognitive function and risks of cardiovascular disease and hypoglycaemia in patients with type 2 diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial
}}
| This area was generated with Dilib version V0.6.33. |  |